Students come to universities with various backgrounds and different levels of preparation for learning. Those with limited educational attainment often struggle in the typical one-size-fits-all university curriculum. Differentiated instruction (DI) has been shown to help younger students with varying skill levels achieve learning goals but has not been applied broadly in higher education. This session will discuss where, when, and how DI can best be used to promote more equitable outcomes in the college classroom without taking on substantial additional effort. Participants will explore practical tips for differentiating instruction in terms of content, process, product, and environment, and they will develop their own strategies for infusing DI into current classroom practices. The session will include examples, case studies, self-assessment tools and additional resources.